Direct current (DC) nerve block has been shown to provide a complete block of nerve conduction without unwanted neural firing. Previous work shows that high capacitance electrodes can be used to safely deliver a DC block. Another way of delivering DC safely is through a separated interface nerve electrode (SINE), such that any reactive species that are generated by the passage of DC are contained in a vessel away from the nerve.
Type 2 diabetes mellitus (T2DM) increases the risk of amnestic mild cognitive impairment (aMCI) and Alzheimer’s disease(AD). aMCI is the transitory stage from normal cognition to AD, which seriously impacts the quality of human life, especially for old people.